The Magee Lab

The lab is interested in understanding how brains learn.

• Our long-term goal is to establish the circuit and cellular level mechanisms by which cortical representations are modified by experience and to determine how these learned representations improve behavior. 

• We are currently examining how the various elements of a newly discovered form of synaptic plasticity (BTSP) are involved in producing learning-related changes in neuronal representations in several cortical areas (hippocampus, entorhinal cortex and barrel cortex). 

• We use intracellular and extracellular electrical recordings as well as 2-photon optical imaging techniques to record from both single neurons and populations in behaving mice and brain slices.  We also employ various opto- and chemo-genetic techniques to manipulate circuits.

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